Andrographolide is a medicinal compound known to fight SARS-CoV-2, but its exact cellular targets in human lung cells were previously unclear. This study investigated the specific cellular pathways it activates to block the virus.

Key Findings

• Pathway Activation: Proteomic analysis revealed that andrographolide activates the NRF2 pathway, a cellular defense system against stress.
• Glutathione Restoration: SARS-CoV-2 infection depletes glutathione (a vital antioxidant) in lung cells. Andrographolide triggers the enzymes (GCLC and GCLM) needed to rebuild and restore glutathione levels.
• Antiviral Effect: Artificially boosting GCLC or treating cells with an antioxidant significantly reduced SARS-CoV-2 infection.

The Takeaway Andrographolide fights COVID-19 by boosting the lung’s natural antioxidant defenses. Targeting glutathione production offers a promising therapeutic strategy against SARS-CoV-2.

Read more: https://pmc.ncbi.nlm.nih.gov/articles/PMC12849096/

First Author: Jarinya Chaopreecha

Corresponding Authors: Arunee Thitithanyanont and Patompon Wongtrakoongate